Journal
BIOMACROMOLECULES
Volume 11, Issue 2, Pages 430-438Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm901151g
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Funding
- Greek General Secretariat of Research and Technology [EPAN YB/39]
- Ministry of Education through the Program Polymer Science and its Applications
- Research Committee of the University of Athens
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We synthesized a series of well-defined poly(DL-lactide)-b-poly(N,N-dimethylamino-2-ethyl methacrylate) (PDLLA-b-PDMAEMA) amphiphilic diblock copolymers by employing a three-step procedure (a) ring-opening polymerization (ROP) of DL-lactide using n-decanol and stannous octoate, Sn(Oct)(2), as the initiating system, (b) reaction of the PDLLA hydroxyl end groups with bromoisobutyryl bromide, and (c) atom transfer radical polymerization, ATRP, of DMAEMA with the newly created bromoisobutyryl initiating site The aggregation behavior of the prepared block copolymers was investigated by dynamic light scattering and potential measurements at 25 degrees C in aqueous solutions of different pH values The hydrophobic drug dipyridamole was efficiently incorporated into the copolymer aggregates in aqueous solutions of pH 7 40 High partition coefficient values were determined by fluorescence spectroscopy.
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