Journal
BIOMACROMOLECULES
Volume 11, Issue 12, Pages 3248-3255Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm101147w
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Funding
- National Science Foundation [DMR- 1041535]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1041535] Funding Source: National Science Foundation
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Polymer hydrogels containing positively charged functional groups were used to investigate the critical material and biological components of FVII activation and subsequent fibrin formation in citrated plasma. A FVIIa ELISA confirmed the ability of the polymer to induce FVII activation and provided insight into the material parameters which were influential in this activation. Experiments utilizing coagulation factor depleted and inhibited plasmas indicated that FVII, FX, FII, and FI are all vital to the process outlining the general mechanism of fibrin formation from the onset of FVII activation. Dynamic mechanical analysis and swelling experiments were used to establish a critical correlation between polymer microstructure and FVII activation.
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