Journal
BIOMACROMOLECULES
Volume 10, Issue 8, Pages 2033-2042Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm801313q
Keywords
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Funding
- National Natural Science Foundation of China [20836004, 20574042]
- National Basic Research Program [2009CB930602]
- NIH [DE09848]
- Li Ka-shing Foundation
- Chinese Ministry of Education
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Well-defined cell ulose-based dual graft molecular brushes, composed of ethyl cellulose-graft-poly(N,N-dimethylaminoethyl methacrylate)-graft-poly(epsilon-caprolactone) (EC-g-PDMAEMA-g-PCL), have been prepared by ring-opening polymerization (ROP) and atom transfer radical polymerization (ATRP). Unlike other brush copolymers, the new molecular brushes show some unique physicochemical properties and multifunction due to their unique topological structures. These biocompatible copolymers self-assembled to micelles in aqueous solution. Upon pH change, the single micelles further assembled into micellar aggregates. As a result, the micelles in aqueous media could act as excellent drug nanocarriers for controlled drug release. The crystallinity and crystal morphology of the copolymers can be controlled to a certain extent by varying the length of the side chains, which may exert strong spacial restriction and, hence, affect the crystal structures.
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