Journal
BIOMACROMOLECULES
Volume 10, Issue 7, Pages 1846-1853Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm900283x
Keywords
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Funding
- 21st Century COE program Nature-Guided Materials Processing of the Ministry of Education, Culture, Sport, Science and Technology (MEXT) of Japanese Government
- special Coordination Funds for Promoting Science and Technology from the MEXT of Japan
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Galacto-trehalose (GT) is a novel class of 1,1'-linked nonreducing disaccharide having an alpha-galactoside epitope. In this study, a pair of alpha,alpha- and alpha,beta-GT isomers were prepared in one pot with our alpha-glycosylation method, converted into vinyl monomers and then subjected to radical copolymerization with a second sugar (4-acrylamidophemyl beta-Glc or beta-GlcNAc) in the presence of acrylamide. The derived glycopolymers were assayed with alpha-galactoside-specific proteins (BSI-B-4 lectin and Shiga toxin-1) to show the results that both alpha,alpha- and alpha,beta-isomers are recognized by these carbohydrate-binding proteins more strongly in forms of the GT polymers. Moreover, the glycopolymer carrying both alpha,alpha-GT and beta-GlcNAc along the polymer chain showed an integrated detoxifying activity to the E. coli toxin as the result of a module effect of the second sugar.
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