Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 28, Issue 9, Pages 1370-1378Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0891-5849(00)00216-1
Keywords
ox-LDL; oxysterols; atherosclerosis; 4-hydroxynonenal; lipid peroxidation; free radicals; transforming growth factor beta 1; fibrosclerosis
Funding
- PHS HHS [E503466] Funding Source: Medline
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The recent research on the impact that oxidative changes of biolipids could have in pathophysiology serves to explain how free radical-driven reactions not only are considered as mere toxicologic events, but also modulators of cell activity and function. Oxidatively modified low-density lipoproteins are known to affect various cellular processes by modulating various molecular pathways and signaling nuclear transcription, Among the lipid oxidation products detectable in ox-LDLs, and also in the atherosclerotic plaques, 4-hydroxynonenal has been widely investigated. This aldehyde was shown to upregulate AP-1 transcription factor, signaling through the MAP kinase pathway, with eventual nuclear localization and induction of a series of genes. Further, oxidation products of cholesterol and cholesterol esters, in ox-LDL are of similar interest, especially in relation to the pathogenesis of fibrosclerotic lesions of the arterial wall. (C) 2000 Elsevier Science Inc.
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