Journal
BIOMACROMOLECULES
Volume 10, Issue 10, Pages 2847-2851Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm900678r
Keywords
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Funding
- Australian Research Council for Federation Fellowship Award
- UNSW Vice Chancellor's Postdoctoral Research Fellowship
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A novel midchain-functional chain transfer agent was synthesized and used as a reversible addition-fragmentation chain transfer polymerization agent to prepare branched poly(N-(2-hydroxypropyl) methacrylamide) (PHPMA). The P(HPMA) contained a thio-reactive group, namely, pyridyldisulfide midchain. The synthesized polymers were fully analyzed by H-1 NMR, GPC, and hydrolysis, confirming well-defined structures (predesigned molecular weights, narrow polydispersities, and high functionalization efficiencies). These midfunctionalized polymers were incubated with bovine serum albumin to generate protein-polymer conjugates. This straightforward methodology for the synthesis of branched midfunctionalized polymers for protein conjugation has the potential to enhance the properties of polymer-protein conjugates by improving biomolecule stability and enhancing circulation time.
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