Journal
BIOMACROMOLECULES
Volume 10, Issue 6, Pages 1392-1401Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm8014973
Keywords
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Funding
- European NoE EXPERTISSUES [NMP3-CT-2004-500283]
- European STREP HIPPOCRATES [NMP3-CT-2003-505758]
- Portuguese Foundation for Science and Technology (FCT) [PTDC/FIS/68517/2006, SFRH/BD/39486/2007]
- Fundação para a Ciência e a Tecnologia [PTDC/FIS/68517/2006, SFRH/BD/39486/2007] Funding Source: FCT
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One of the major drawbacks found in most bone tissue engineering approaches developed so far consists in the lack of strategies to promote vascularisation. Some studies have addressed different issues that may enhance vascularisation in tissue engineered constructs, most of them involving the use of growth factors (GFs) that are involved in the restitution of the vascularity in a damaged zone. The use of sustained delivery systems might also play an important role in the re-establishment of angiogenesis. In this study, kappa-carrageenan, a naturally occurring polymer, was used to develop hydrogel beads with the ability to incorporate GFs with the purpose of establishing an effective angiogenesis mechanism. Some processing parameters were studied and their influence on the final bead properties was evaluated. Platelet derived growth factor (PDGF-BB) was selected as the angiogenic factor to incorporate in the developed beads, and the results demonstrate the achievement of an efficient encapsulation and controlled release profile matching those usually required for the development of a fully functional vascular network. In general, the obtained results demonstrate the potential of these systems for bone tissue engineering applications.
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