Journal
NEOPLASIA
Volume 2, Issue 3, Pages 208-225Publisher
ELSEVIER SCIENCE INC
DOI: 10.1038/sj.neo.7900073
Keywords
phosphorylation; blocked RNA polymerase II; nucleocytoplasmic shuttling; MDM2; proteasome
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Funding
- NCI NIH HHS [CA82376-01] Funding Source: Medline
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The tumor suppressor protein, p53, is part of the cell's emergency team that is called upon following cellular insult. How do cells sense DNA damage and other cellular stresses and what signal transduction pathways are used to alert p53? How is the resulting nuclear accumulation of p53 accomplished and what determines the outcome of p53 induction? Many posttranslational modifications of p53, such as phosphorylation, dephosphorylation, acetylation and ribosylation, have been shown to occur following cellular stress. Some of these modifications may activate the p53 protein, interfere with MDM2 binding and/or dictate cellular localization of p53, This review will focus on recent findings about how the p53 response may be activated following cellular stress.
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