Journal
BIOMACROMOLECULES
Volume 9, Issue 11, Pages 3039-3043Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm800479e
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Funding
- National Science Foundation [CCF-0622093]
- National Institute of Health [R21EB007472]
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This work explores using self-assembled DNA nanostructures as carriers for drug delivery. We have recently developed an organic nanotube system that is assembled from a single component: a 52-base-long DNA single strand. In this work, functional agents (folate as a cancer cell target agent and Cy3 as a fluorescence imaging agent) are conjugated with the DNA strands; the conjugates self-assemble into micrometers-long nanotubes (NTs). The conjugated DNA-NTs can be effectively taken by cancer cells as demonstrated by fluorescence imaging and fluorescence-activated cell sorting. No obvious toxicity has been observed under current experimental conditions.
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