Journal
BIOMACROMOLECULES
Volume 9, Issue 6, Pages 1604-1612Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm8000759
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Funding
- NIDCR NIH HHS [DE 13207] Funding Source: Medline
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Poly (anhydride-esters) based on iodinated versions of salicylic acid were synthesized via both melt-condensation and solution polymerization techniques to generate radiopaque biomaterials. The poly (anhydride-esters) from iodinated salicylates were highly X-ray opaque compared to poly (anhydride-esters) from salicylic acid. Molecular weight and Young's modulus of polymers prepared by melt-condensation were typically two-to-three times higher than polymers prepared by solution methods. The glass transition temperatures of the polymers were dependent on the iodine concentration; polymers containing more iodine had higher glass transition temperatures. Cytotoxicity studies using mouse fibroblasts indicated that iodinated salicylate-based poly(anhydride-esters) prepared by both polymerization methods are biocompatible with cells at low polymer concentrations (0.01 mg/mL).
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