Journal
AMERICAN JOURNAL OF NEPHROLOGY
Volume 20, Issue 3, Pages 201-207Publisher
KARGER
DOI: 10.1159/000013584
Keywords
cardiac function; hemodialysis; left ventricular mass; L-carnitine supplementation
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Cardiac diseases are well known among patients on maintenance hemodialysis (HD), and carnitine deficiency may be an important factor in cardiac morbidity. We studied the effects of low-dose L-carnitine treatment (500 mg/day) on chest symptoms (dyspnea on exertion, chest pain, palpitation), cardiac function, and left ventricular (LV) mass in 9 HD patients with reduced ejection fraction (EF). After 6 months of L-carnitine treatment, most patients had at least some improvement in chest symptoms, while LVEF was increased and LV mass was decreased. Carnitine fractions increased and reached plateaus at 2-3 times the baseline levels. These results suggest that prolonged low-dose L-carnitine treatment can improve the cardiac morbidity by restoring decreased carnitine tissue levels and impaired oxidation of FFA, Copyright (C) 2000 S. Karger AG, Basel.
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