Journal
BIOMACROMOLECULES
Volume 9, Issue 10, Pages 2891-2897Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm8006715
Keywords
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Funding
- Oligasis Corporation
- Materials Research Science and Engineering Center (MRSEC)
- NSF-CBET [0553597]
- Division Of Physics
- Direct For Mathematical & Physical Scien [0553597] Funding Source: National Science Foundation
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Polymer-protein conjugation was performed using N-hydroxysuccinimide and aldehyde-terminated zwitterionic polymers, and the resulting polymer-protein conjugates were characterized by gel electrophoresis and fast protein liquid chromatography. Methacryloyloxyethyl phosphorylcholine (MPC) polymers were prepared by atom transfer radical polymerization in which the requisite functional end-groups for protein conjugation were embedded within the polymerization initiators. These phosphorylcholine polymers were conjugated to lysozyme as a model protein, as well as two therapeutic proteins, granulocyte colony stimulating factor (G-CSF) and erythropoietin (EPO). These MPC polymer-protein conjugates represent alternatives to PEGylated proteins, with the potential to provide improved efficacy in a therapeutic treatment relative to the protein itself.
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