Journal
BIOLOGY OF THE CELL
Volume 106, Issue 6, Pages 167-181Publisher
WILEY
DOI: 10.1111/boc.201400008
Keywords
Cardiovascular development; Cardiogenesis; Reactive oxygen species; ROS; Sphingolipids
Categories
Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [301149/2012-7]
- Programa Institutos Nacionais de Ciencia e Tecnologia (INCT de Processos Redox em Biomedicina-REDOXOMA) [573530/2008-4]
- Fundacao de Amparo a Pesquisa do Rio Grande do Sul FAPERGS (PRONEM ) [11/2072-2]
- Programa Binacional de Terapia Celular Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (PROBITEC-CAPES) [004/12]
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The heart is the first organ in the embryo to form. Its structural and functional complexity is the result of a thorough developmental program, where sphingolipids play an important role in cardiogenesis, heart maturation, angiogenesis, the regulation of vascular tone and vessel permeability. Sphingolipids are necessary for signal transduction and membrane microdomain formation. In addition, recent evidence suggests that sphingolipid metabolism is directly interconnected to the modulation of oxidative stress. However, cardiovascular development is highly sensitive to excessive reactive species production, and disturbances in sphingolipid metabolism can lead to abnormal development and cardiac disease. Therefore, in this review, we address the molecular link between sphingolipids and oxidative stress, connecting these pathways to cardiovascular development and cardiovascular disease.
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