Journal
JOURNAL OF ETHNOPHARMACOLOGY
Volume 70, Issue 2, Pages 171-176Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0378-8741(99)00146-4
Keywords
Phyllanthus emblica fruits; gastric ulcer; antioxidant; free radical scavenger
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Pretreatment with the butanol extract of the water fraction of Phyllanthus emblica fruits at the dose of 100 mg/kg body-weight, orally administered to rats for 10 consecutive days, was found to enhance secretion of gastric mucus and hexosamine (P < 0.001) in the indomethacin induced ulceration of rats. The morphological observations also supported a protective effect of the stomach wall from lesion. The indomethacin treatment of the premedicated animals with the drug hardly affected either the malondialdehyde (MDA) or superoxide dismutase (SOD) level in gastric tissue while the ulcerative agent itself significantly enhanced both the levels. An antioxidant property appears to be predominantly responsible for this cytoprotective action of the drug. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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