Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 129, Issue 5, Pages 423-424Publisher
CONSULTANTS BUREAU
DOI: 10.1007/BF02439790
Keywords
DAGO; DSLET; dinorphin A(1-13); opiate receptors; myocardial ischemia; cardiac arrhythmias
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In acute experiments on Nembutal-anesthetized cats, the effect of opiate receptor agonists DAGO, DSLET, and dinorphin A(1-13) on the incidence of idioventricular rhythm disturbances, including ventricular tachycardia and fibrillation, was studied under conditions of occlusion of circumflex branch of the left coronary artery and stimulation of the sensorimotor cortex. The most pronounced effects were observed with DSLET and dinorphin A(1-13). These preparations completely prevented ventricular fibrillation. DAGO produced a less pronounced protective effect probably because of parallel increase in plasma catecholamine concentration.
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