Journal
TRENDS IN MICROBIOLOGY
Volume 8, Issue 5, Pages 221-225Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0966-842X(00)01739-X
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Many methanotrophs contain both a soluble and a particulate methane monooxygenase. A unique metabolic switch, mediated by copper ions, regulates the expression of these enzymes. When the copper-to-biomass ratio of the cell is low, the soluble enzyme is expressed, and when the copper-to-biomass ratio is high, the particulate enzyme is expressed. A model for the mechanism of this switch is proposed.
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