Journal
BIOLOGY OF THE CELL
Volume 104, Issue 2, Pages 51-69Publisher
WILEY-BLACKWELL
DOI: 10.1111/boc.201100113
Keywords
Chromatin; Histones; Meiosis; Mitosis; Recombination
Categories
Funding
- Centre National de la Recherche Scientifique
- Association pour la Recherche sur le Cancer
- Fondation pour la Recherche Medicale
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Meiotic recombination lies at the heart of sexual reproduction. It is essential for producing viable gametes with a normal haploid genomic content and its dysfunctions can be at the source of aneuploidies, such as the Down syndrome, or many genetic disorders. Meiotic recombination also generates genetic diversity that is transmitted to progeny by shuffling maternal and paternal alleles along chromosomes. Recombination takes place at non-random chromosomal sites called 'hotspots'. Recent evidence has shown that their location is influenced by properties of chromatin. In addition, many studies in somatic cells have highlighted the need for changes in chromatin dynamics to allow the process of recombination. In this review, we discuss how changes in the chromatin landscape may influence the recombination map, and reciprocally, how recombination events may lead to epigenetic modifications at sites of recombination, which could be transmitted to progeny.
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