Journal
INTERNAL MEDICINE
Volume 39, Issue 5, Pages 412-415Publisher
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.39.412
Keywords
therapy-related myelodysplastic syndrome; secondary leukemia; fusion gene; NUP98/DDX10 fusion
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We report a 50-year-old man who developed therapy-related myelodysplastic syndrome after treatment with etoposide-including chemotherapy for extratesticular germ cell tumor. Chromosomal analysis showed inversion 11 (p15q22) translocation Reverse transcriptase-polymerase chain reaction amplification of patient RNA showed a fusion transcript of nucleoporin gene NUP98, and putative DEAD-box RNA helicase gene DDX10, NUP98 is implicated in the transformation through aberrant nucleocytoplasmic transport. DDX10 is suggested to be involved in ribosome assembly. The NUP98-DDX10 fusion transcript may promote the development of secondary hematological malignancies caused by DNA-topoisomerase II inhibitors through aberrant nucleocytoplasmic transport and/or alteration in ribosome assembly.
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