Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 57, Issue 5, Pages 738-746Publisher
BIRKHAUSER VERLAG AG
DOI: 10.1007/s000180050038
Keywords
klotho; endothelial function; nitric oxide production; hypertension; renal failure; cytokine
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The human aging process is associated with vascular endothelial dysfunction. However, humoral factors which might protect against endothelial dysfunction during aging have not yet been identified. We recently identified the klotho gene as a possible regulator of human aging. In the present study using the klotho-deficient heterozygous mouse, we examined whether the Klotho protein is a humoral factor protecting against endothelial dysfunction. We further clotted rat klotho cDNA and investigated whether klotho mRNA expression in rat kidney is altered under pathological conditions such as hypertension, hyperlipidemia, renal failure, and inflammatory stress. The Klotho protein itself, or its metabolites, promotes endothelial NO production in aorta as well as arterioles, and klotho mRNA in kidney is downregulated under sustained circulatory stress.
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