Journal
TRENDS IN CELL BIOLOGY
Volume 10, Issue 5, Pages 189-196Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0962-8924(00)01738-4
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The function of the nucleolus as a factory for assembling ribosomal subunits is well established, but many unrelated activities have been discovered over the past decade. Our understanding of the dynamics of nucleolar structure and its reassembly at the end of mitosis has recently advanced and the small nucleolar RNAs have been shown to be major players in the processing and modification of preribosomal RNA. Unexpectedly, the nucleolus also seems to play a role in nuclear export, sequestering regulatory molecules, modifying small RNAs, assembling ribonucleoprotein (RNP) and controlling aging.
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