Journal
JOURNAL OF BACTERIOLOGY
Volume 182, Issue 9, Pages 2668-2671Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.182.9.2668-2671.2000
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- NIAID NIH HHS [AI RO1-22159, AI RO1-30138] Funding Source: Medline
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Glycerol monolaurate (GML) inhibits the expression of virulence factors in Staphylococus aureus and the induction of vancomycin resistance in Enterococcus faecalis, presumably by blocking signal transduction. Although GML is rapidly hydrolyzed by bacteria, one of the products, lauric acid, has identical inhibitory activity and is metabolized much more slowly. At least four distinct GML-hydrolyzing activities are identified in S. aureus: the secreted Geh lipase, residual supernatant activity in a geh-null mutant strain, a novel membrane-bound esterase, and a cytoplasmic activity.
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