Journal
INTERNATIONAL IMMUNOLOGY
Volume 12, Issue 5, Pages 631-638Publisher
OXFORD UNIV PRESS
DOI: 10.1093/intimm/12.5.631
Keywords
anti-Ig; B1B cells; B-CLL; cell cycle; chronic lymphocytic leukemia
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Progression into G(1) in a lymphocytes is regulated by cyclins D2 and D3, components of the cell cycle machinery currently believed to have overlapping and potentially redundant roles in cell cycle control. To study the specific role of cyclin D2 in a lymphocyte proliferation, we examined a cells from cyclin D2(-/-) mice and demonstrate a specific requirement for cyclin D2 in BCR- but not CD40- or lipopolysaccharide-induced proliferation. Furthermore, conventional a cell development proceeds normally in the mutant mice; however, the CD5 B cell compartment is dramatically reduced, suggesting that cyclin D2 is important in CD5 a cell development as well as antigen-dependent B cell clonal expansion.
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