Journal
JOURNAL OF NEUROSCIENCE
Volume 20, Issue 9, Pages 3233-3243Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.20-09-03233.2000
Keywords
synaptic plasticity; LTP; hippocampal culture; correlated activity; spike timing; Hebbian; synapse specificity
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Funding
- NINDS NIH HHS [NS 36999, NS 07220, T32 NS007220, R01 NS036999] Funding Source: Medline
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Induction of long-term potentiation (LTP) of the synaptic connection between two hippocampal glutamatergic neurons in a neural network formed in cell culture resulted in a specific pattern of potentiation at other connections within the network. We found that potentiation propagated from the site of induction retrogradely to glutamatergic or GABAergic synapses received by the dendrites of the presynaptic neuron and laterally to those made by its axonal collaterals onto other glutamatergic cells. In contrast, synapses made by the same presynaptic neuron onto GABAergic cells were not affected, and there was no postsynaptic lateral or forward propagation to other synapses received or made by the postsynaptic neuron. In addition, there was no secondary propagation to synapses not directly associated with the presynaptic neuron. Both induction and propagation of LTP required correlated spiking of the postsynaptic cell as well as the activation of the NMDA subtype of glutamate receptors. Such selective propagation suggests the existence of a long-range cytoplasmic signaling within the presynaptic neuron, leading to a specific pattern of coordinated potentiation along excitatory pathways in a neural network.
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