Journal
BIOCONJUGATE CHEMISTRY
Volume 11, Issue 3, Pages 301-305Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bc990168d
Keywords
-
Categories
Funding
- NIAID NIH HHS [R01AI-CA46973] Funding Source: Medline
- NIDDK NIH HHS [R21DK55713] Funding Source: Medline
Ask authors/readers for more resources
A major obstacle to using paramagnetic MR contrast agents for in vivo cell tracking or molecular sensing is their generally low cellular uptake. In this study, we show that a paramagnetically labeled DOTA chelator derivatized with a 13-mer HIV-tat peptide is efficiently internalized into mammalian cells. Intracellular concentrations were attained that were readily detectable by MR imaging using both gadolinium and dysprosium chelates. Using this paradigm, it should be feasible to internalize a variety of chemically different agents into mammalian cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available