Journal
DRUG AND ALCOHOL DEPENDENCE
Volume 59, Issue 2, Pages 101-123Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0376-8716(99)00109-X
Keywords
substance abuse; genotype-environment interaction; behavioral phenotype
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Funding
- NIDA NIH HHS [DA08955, DA05605] Funding Source: Medline
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Genetic studies of substance abuse indicate that variation in the risk for the disorder in the population is contributed by differences in both individual genotypes and environment. Recent developments in genetics raise the possibility of disentangling the complex system of genotype-environment interaction that determines the development of the individual behavioral phenotype. This paper reviews the concepts, methods and results pertaining to genetic investigation of substance abuse. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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