Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 377, Issue 1, Pages 135-138Publisher
ACADEMIC PRESS INC
DOI: 10.1006/abbi.2000.1765
Keywords
1,25-dihydroxyvitamin D-3; IL-4; EAE; transplantation
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Funding
- NIDDK NIH HHS [DK14881] Funding Source: Medline
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The active form of vitamin D (1,25-(OH)(2)D-3) is a potent immune system regulator. In vivo the oral administration of 1,25-(OH)(2)D-3 completely prevents experimental autoimmune encephalomyelitis (EAE), significantly prolongs allograft survival, and prevents collagen-induced arthritis. 1,25-(OH)(2)D-3 given to mice increased IL-4 protein and transcript levels. We have now tested the efficacy of 1,25-(OH)(2)D-3 on EAE development and allograft survival in IL-4-deficient [knockout (ko)] mice. 1,25-(OH)(2)D-3 was found to be much less effective in the absence of IL-4, suggesting that IL-4 production is a significant factor in the action of 1,25-(OH)(2)D-3 on the immune system. (C) 2000 Academic Press.
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