Journal
SCHIZOPHRENIA RESEARCH
Volume 42, Issue 3, Pages 209-222Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0920-9964(99)00131-0
Keywords
frontal lobe; memory organization; regional cerebral blood flow; schizophrenia; single photon emission computed tomography
Categories
Ask authors/readers for more resources
Regional cerebral blood flow (rCBF) during a verbal learning task was measured using Tc-99m-ethyl-cysteinate dimer and single photon emission computed tomography in 10 patients with schizophrenia and nine normal controls. Verbal repetition was used as a control task. The schizophrenic patients showed failure to spontaneously utilize implicit category information to learn the word lists. In the normal controls, rCBF in the left inferior frontal and left anterior cingulate regions was significantly increased during the verbal learning task, compared with the verbal repetition task. In contrast, there was no significant frontal lobe activation by the verbal learning in the schizophrenic patients. The patients had lower rCBF during the verbal learning task than the controls in the bilateral inferior frontal, left anterior cingulate, right superior frontal, and bilateral middle frontal regions. Activation in the left inferior frontal region was significantly positively correlated with categorical clustering in the task in the controls, but no such correlation was found in the patients. These results indicate that memory organization deficits in schizophrenia may be related to dysfunction in the prefrontal areas, especially in the left inferior frontal region. (C) 2000 Elsevier Science B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available