Journal
NEUROLOGY
Volume 54, Issue 9, Pages 1848-1850Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.54.9.1848
Keywords
creatine; therapy; muscular dystrophy; dietary supplement
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The authors assessed the safety and efficacy of creatine monohydrate (Cr) in various types of muscular dystrophies in a double-blind, crossover trial. Thirty-six patients (12 patients with facioscapulohumeral dystrophy, 10 patients with Becker dystrophy, 8 patients with Duchenne dystrophy, and 6 patients with sarcoglycan-deficient limb girdle muscular dystrophy) were randomized to receive Cr or placebo for 8 weeks. There was mild but significant improvement in muscle strength and daily-life activities by Medical Research Council scales and the Neuromuscular Symptom Score. Cr was well tolerated throughout the study period.
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