Journal
FEBS LETTERS
Volume 473, Issue 2, Pages 145-148Publisher
WILEY
DOI: 10.1016/S0014-5793(00)01517-9
Keywords
lipid peroxidation; alpha-tocopherol; glutathione; flavonoid; antioxidant; free radical reductase
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Endogenous antioxidants such as the lipid-soluble vitamin E protect the cell membranes from oxidative damage. Glutathione seems to be able to regenerate alpha-tocopherol via a so-called free radical reductase, The transient protection by reduced glutathione (GSH) against lipid peroxidation in control liver microsomes is not observed in microsomes deficient in alpha-tocopherol. Introduction of antioxidant flavonoids, such as 7-monohydroxyethylrutoside, fisetin or naringenin, into the deficient microsomes restored the GSH-dependent protection, suggesting that flavonoids can take over the role of alpha-tocopherol as a chain-breaking antioxidant in liver microsomal membranes. (C) 2000 Federation of European Biochemical Societies.
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