Journal
NEUROREPORT
Volume 11, Issue 7, Pages 1483-1485Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200005150-00024
Keywords
interleukin-2; analgesic effect; Leu-enkephalin; neuroimmunomodulation; nuclei; opioid receptors; pain threshold
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Interleukin-2 (IL-2) was found to have an analgesic effect in both central and peripheral nervous systems. This effect is related to opioid receptors and mediated mainly by IL-2 directly binding to opioid receptors. Using radioimmunoassay, the content of Leu-enkephalin (LEK) in some nuclei were measured at intervals after the injection of IL-2 into the lateral ventricle of rats. Levels of LEK increased in both paraventricular hypothalamic nucleus (PVN) and locus ceruleus (LOC) after IL-2 administration, suggesting that the analgesic effect of IL-2 is also related to the change of LEK in PVN and LOC induced by IL-2 administration. NeuroReport 11:1483-1485 (C) 2000 Lippincott Williams & Wilkins.
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