Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 28, Issue 10, Pages 1478-1486Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0891-5849(00)00248-3
Keywords
S-nitrosothiols; S-nitrosoglutathione; nitric oxide; thiols; nitrosation thiolation; free radicals
Funding
- NCRR NIH HHS [RR01008] Funding Source: Medline
- NIGMS NIH HHS [GM55792] Funding Source: Medline
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S-Nitrosothiols are endogenous metabolites of nitric oxide that have been detected in extra- and intracellular spaces. Many biological functions of S-nitrosothiols have been described that can be categorized as being due to one or more of the following: (i) nitric oxide release, (ii) transnitrosation, (iii) S-thiolation, and (iv) direct action. This emphasizes the fact that S-nitrosothiols are more than simply nitric oxide donors. Many of the biological functions that have been described for S-nitrosothiols have clinical correlates. This review describes the biological chemistry, biological actions, and clinical potential of these compounds. (C) 2000 Elsevier Science Inc.
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