Journal
NEUROSCIENCE LETTERS
Volume 285, Issue 3, Pages 165-168Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3940(00)01037-5
Keywords
Alzheimer's disease; microglia; neurofibrillary tangles
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Funding
- NIA NIH HHS [P30AG10182] Funding Source: Medline
- NICHD NIH HHS [HD02528] Funding Source: Medline
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It has been postulated that microglia contribute to the development of neurofibrillary tangles (NFT) in Alzheimer's disease (AD). We compared the distribution of microglia with that of NTT in both AD and non-AD cases. In AD cases, we found that the extent of area covered by Ricinus communic agglutinin-1 labeled microglia generally paralleled NFT frequency and distribution. Microglia occupied the greatest area in tangle-rich periallocortex/allocortex, a lesser area in association cortex, and the smallest area in tangle-poor primary cortex. Interestingly, this pattern was also present in non-AD cases where there were few to no NFT. These findings suggest that regional variations in microglial distribution may constitute, at least in part, a template for the development of NFT. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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