Journal
FEBS LETTERS
Volume 473, Issue 3, Pages 311-315Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(00)01547-7
Keywords
galectin-3; oxidative balance; cell injury; cell death
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Galectins are a family of proteins involved in several cell processes, including their survival and death. Galectin-3 has in particular been described as an anti-apoptotic molecule entangled with a number of subcellular activities including anoikis resistance. In this work me partially address the mechanisms underlying this activity painting at two key factors in injury progression: the alteration of mitochondrial membrane potential and the formation of reactive oxygen species. Over-expression of galectin-3 appears in fact to exert a protective effect towards both these events. On the basis of these data, me propose a reappraisal of the role of galectin-3 as a regulator of mitochondrial homeostasis. (C) 2000 Federation of European Biochemical Societies.
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