Journal
TETRAHEDRON LETTERS
Volume 41, Issue 20, Pages 3997-4001Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(00)00537-2
Keywords
amino acids and derivatives; solid phase synthesis; peptides and polypeptides
Categories
Ask authors/readers for more resources
A versatile safety catch backbone-amide protection system (1, 2) has been developed to inhibit interchain aggregation during solid phase peptide synthesis. The strategy utilises the N-alpha-Fmoc derivative of an N-(3-methylsulfinyl-4-methoxy-6-hydroxybenzyl) (SiMB, 2) substituted amino acid (5b), a group which exhibits excellent all round coupling kinetics. The value of these improved derivatives is demonstrated through the syntheses of leucine enkephalinamide (9) and the well known 'difficult sequence' from the acyl carrier protein, residues (65-74) (10) via standard uronium activation and pentafluorophenyl eater chemistry. (C) 2000 Elsevier Science Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available