Journal
FEBS LETTERS
Volume 474, Issue 1, Pages 71-75Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(00)01570-2
Keywords
muscle development; muscle regeneration; muscular dystrophy; TGF-beta
Funding
- NHLBI NIH HHS [HL61322, HL10288] Funding Source: Medline
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Myostatin, a TGP-beta family member, is a negative regulator of muscle growth, Here, me generated transgenic mice that expressed myostatin mutated at its cleavage site under the control of a muscle specific promoter creating a dominant negative myostatin, These mice exhibited a significant (20-35%) increase in muscle mass that resulted from myofiber hypertrophy and not from myofiber hyperplasia. We also evaluated the role of myostatin in muscle degenerative states, such as muscular dystrophy, and found significant downregulation of myostatin, Thus, further inhibition of myostatin mag permit increased muscle growth in muscle degenerative disorders. (C) 2000 Federation of European Biochemical Societies.
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