Journal
SCIENCE
Volume 288, Issue 5470, Pages 1379-1384Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.288.5470.1379
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In eukaryotic cells, sister DNA molecules remain physically connected from their production at S phase until their separation during anaphase. This cohesion is essential for the separation of sister chromatids to opposite poles of the cell at mitosis. It also permits chromosome segregation to take place long after duplication has been completed. Recent work has identified a multisubunit complex called cohesin that is essential for connecting sisters. Proteolytic cleavage of one of cohesin's subunits may trigger sister separation at the onset of anaphase,
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