Journal
NEUROSCIENCE LETTERS
Volume 286, Issue 1, Pages 21-24Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3940(00)01074-0
Keywords
neurogenesis; dentate gyrus; learning; 5-bromo-2 '-deoxyuridine; cell survival; rat
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Neurogenesis occurs throughout life in mammalian dentate gyrus. The effect of learning on newborn cell survival was studied in rat. Rats were trained on a hippocampus-dependent spatial learning task by using Morris water maze. Neurogenesis was evaluated by 5-bromo-2'deoxyuridine administered before learning. Several newborn cells expressed the immature neuron marker TOAD-64. The main findings were as follows: (1) the survival of newborn cells was enhanced by learning at early stage of differentiation; (2) the newborn cells saved by learning were mainly located in the rostral pare of external blade of granule cell layer and (3) there was a correlation between the actual individual learning and newborn cell survival. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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