Journal
JOURNAL OF CELL BIOLOGY
Volume 149, Issue 5, Pages 1005-1010Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.149.5.1005
Keywords
protein kinase; dosage compensation; Drosophila; chromatin; MSL complex
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JIL-1 is a novel chromosomal kinase that is upregulated almost twofold on the male X chromosome in Drosophila. Here we demonstrate that JIL-1 colocalizes and physically interacts with male specific lethal (MSL) dosage compensation complex proteins. Furthermore, ectopic expression of the MSL complex directed by MSL2 in females causes a concomitant upregulation of JIL-1 to the female X that is abolished in msl mutants unable to assemble the complex. Thus, these results strongly indicate JIL-1 associates with the MSL complex and further suggests JIL-1 functions in signal transduction pathways regulating chromatin structure.
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