Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 15, Issue 6, Pages 1132-1137Publisher
WILEY
DOI: 10.1359/jbmr.2000.15.6.1132
Keywords
osteoporosis; idiopathic osteoporosis; bone mineral density; segregation analysis
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Although there have been a number of studies indicating a heritable component for osteoporosis in middle to late adulthood, the etiology of osteoporosis in young people is uncertain. The present study aims to evaluate the extent to which genetic factors influence familial resemblance for bone mineral density (BMD) in families ascertained on the basis of young osteoporotic probands, The sample comprises eight families (74 total individuals) that were identified through a proband under the age of 35 years with a history of two or more fractures and a spinal bone density of at least 2.5 SDs below the mean for age and sex (Z score). Secondary causes of osteoporosis were excluded in the probands. In total, 27% (18/66) of the probands' relatives had osteoporosis and an additional 30% (20/66) had osteopenia, Classical segregation analysis was performed to evaluate the extent to which a genetic etiology could account for familial resemblance in these families, The results indicate a major gene of codominant inheritance for spinal BMD, Model-fitting comparisons revealed no support for environmental effects or for polygenic inheritance.
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