Journal
JOURNAL OF BACTERIOLOGY
Volume 182, Issue 12, Pages 3593-3596Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.182.12.3593-3596.2000
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Funding
- NIGMS NIH HHS [R01 GM058213, GM58213] Funding Source: Medline
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Although exopolysaccharides (EPSs) are a large component of bacterial biofilms, their contribution to biofilm structure and function has been examined for only a few organisms. In each of these cases EPS has been shown to be required for cellular attachment to abiotic surfaces. Here, we undertook a genetic approach to examine the potential role of colanic acid, an EPS of Escherichia coli K-12, in biofilm formation. Strains either proficient or deficient in colanic acid production were groan and allowed to adhere to abiotic surfaces and were then examined both macroscopically and microscopically. Surprisingly, we found that colanic acid production is not required for surface attachment. Rather, colanic acid is critical for the formation of the complex three-dimensional structure and depth of E. coli biofilms.
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