Journal
MECHANISMS OF DEVELOPMENT
Volume 94, Issue 1-2, Pages 271-275Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(00)00293-8
Keywords
aldo-keto reductase; aldehyde reductase; aldose reductase; limb; limb bud; lung; terminal bronchi; neural ectoderm; gut endoderm; epithelium; tailbud; neural tube; branchial arches; kidney
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The aldo-keto reductase superfamily catalyzes the reduction of a broad range of aldehydes and ketones to their corresponding alcohols. Here we report the cloning of the mouse aldehyde reductase cDNA and its embryonic pattern of expression. From stages E7.5 to E13.5 the gene encoding for this enzyme is expressed at high levels in several tissues, including the neural ectoderm, gut endoderm, somites, branchial arches, otic vesicles, limb buds, and tail bud. In adult mice aldehyde reductase was expressed in all tissues examined. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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