Journal
BRITISH JOURNAL OF SURGERY
Volume 87, Issue 6, Pages 808-813Publisher
BLACKWELL SCIENCE LTD
DOI: 10.1046/j.1365-2168.2000.01424.x
Keywords
-
Categories
Ask authors/readers for more resources
Background: Gut protein loss is a characteristic of inflammatory bowel disease (IBD), and immunoglobulin (Ig) G, albumin and alpha(1)-antitrypsin concentrations in whole gut lavage fluid (WGLF) correlate with clinical disease activity. If inflammation in ileoanal pouches is similar to IBD, then measurement of protein-losing enteropathy by analysis of WGLF may provide an objective assessment of disease activity in pouches. Methods: Forty-two patients who had restorative proctocolectomy for ulcerative colitis underwent whole gut lavage with a polyethylene glycol-electrolyte solution. The first dear effluent was filtered, processed by the addition of protease inhibitors and stored at -70 degrees C. IgG, albumin and alpha(1)-antitrypsin were assayed in WGLF. The Pouchitis Disease Activity Index (PDAI) was calculated after pouchoscopy and biopsy; the Moskowitz criteria for pouchitis were also applied. Results: There was a significant correlation of the pouchoscopy score and the PDAI with the concentration of WGLF IgG. All patients with 'pouchitis' according to the Moskowitz criteria had a WGLF IgG concentration greater than 10 mu g/ml. The WGLF albumin level also showed a significant correlation with the PDAI, but alpha(1)-antitrypsin concentration did not. Conclusion: Analysis of WGLF for IgG and albumin may be useful in the assessment of disease activity in pouch inflammation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available