Journal
EUROPEAN JOURNAL OF CANCER
Volume 36, Issue 10, Pages 1269-1274Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0959-8049(00)00091-5
Keywords
Rac; Rho; adherens junctions; E-cadherin; cell migration; Tiam1
Categories
Ask authors/readers for more resources
Cell migration and the regulation of cadherin-mediated homotypic cell-cell interactions are critical events during development, morphogenesis and wound healing. Aberrations in signalling pathways involved in the regulation of cell migration and cadherin-mediated cell-cell adhesion contribute to tumour invasion and metastasis. The rho family proteins, including cdc42, racl and rhoA, regulate signalling pathways that mediate the distinct actin cytoskeleton changes required for both cellular motility and cell-cell adhesion. Recent studies indicate that rac directly influences rho activity at the GTPase level and that the reciprocal balance between rac and rho activity can determine epithelial or mesenchymal cell morphology and migratory behaviour of epithelial (tumour) cells. (C) 2000 Elsevier Science Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available