Journal
ACCOUNTS OF CHEMICAL RESEARCH
Volume 33, Issue 6, Pages 346-353Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ar990084k
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The development of an efficient catalytic system for enantioselective carbon-carbon bond formation by 1,4-addition of organometallic reagents (organolithium, Grignard, and organozinc reagents) to enones is a major challenge in organic synthesis. This Account presents the breakthrough realized in this field using chiral phosphoramidite ligands for copper-catalyzed dialkylzinc additions. Applications in catalytic routes to cycloalkanones as well as tandem and annulation procedures with excellent enantioselectivities are discussed.
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