Journal
JOURNAL OF NEUROCHEMISTRY
Volume 74, Issue 6, Pages 2227-2238Publisher
WILEY-BLACKWELL
DOI: 10.1046/j.1471-4159.2000.0742227.x
Keywords
serine protein kinase; gene expression; depolarization; kainic acid; PC12 cells; representational difference analysis
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Funding
- NIAMS NIH HHS [AR01870] Funding Source: Medline
- NINDS NIH HHS [NS18427, NS28660] Funding Source: Medline
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Membrane depolarization of neurons is thought to lead to changes in gene expression that modulate neuronal plasticity, We used representational difference analysis to identify a group of cDNAs that are induced by membrane depolarization or by forskolin, but not by neurotrophins or growth factors, in PC12 pheochromocytoma cells. One of these genes, SIK ((s) over bar alt-(i) over bar nducible (k) over bar inase), is a member of the sucrose-nonfermenting 1 protein kinase/AMP-activated protein kinase protein kinase family that was also recently identified from the adrenal gland of rats treated with high-salt diets. SIK mRNA is induced up to eightfold in specific regions of the hippocampus and cortex in rats, following systemic kainic acid administration and seizure induction.
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