Journal
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
Volume 28, Issue 2, Pages 105-111Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1574-695X.2000.tb01463.x
Keywords
neutrophil defensin; adherence; epithelial cell; respiratory pathogen
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Adherence of Haemophilus influenzae to bronchial epithelial cells is enhanced by neutrophil defensins. which are released from activated neutrophils during inflammation [Gorter et al. (1998) J. Infect. Dis. 178, 1067-1078]. In this study. we showed that the adherence of H. influenzae to various epithelial, fibroblast-like and endothelial cell types was significantly enhanced by defensins (20 mu g ml(-1)). Defensins stimulated also the adherence of Moraxella catarrhalis, Neisseria meningitidis and nonencapsulated Streptococcus pneumoniae to the NCI-H292 cell line, In contrast, defensins did not affect the adherence of Pseudomonas aeruginosa, encapsulated S. pneumoniae, Escherichia coli and Staphylococcus epidermidis. These results suggest that the defensin-enhanced adherence might support the adherence and possibly persistence of the selected bacterial species using the respiratory tract as port of entry. (C) 2000 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
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