Journal
JOURNAL OF VIROLOGY
Volume 74, Issue 11, Pages 5347-5351Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.74.11.5347-5351.2000
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Funding
- NIAID NIH HHS [R01-AI43695] Funding Source: Medline
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The present study sought to determine how usage of coreceptors by human immunodeficiency virus type 1 dictates cell tropism and depletion of CD4(+) T cells in human lymphoid tissues cultured ex vivo. We found that coreceptor preferences control the marked, preferential depletion of coreceptor-expressing CD4(+) lymphocytes. In addition, there was a strong, but not absolute, preference shown by CXCR4-using strains for lymphocytes and by CCR5-using strains for macrophages.
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