Journal
INFECTION AND IMMUNITY
Volume 68, Issue 6, Pages 3704-3709Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.68.6.3704-3709.2000
Keywords
-
Categories
Ask authors/readers for more resources
Trehalose 6,6'-dimycolate (TDM) is a cell surface molecule of Mycobacterium tuberculosis. TDM induced a loss of body weight and prominent granulomas in the fiver and lungs by the intravenous injection of TDM into rabbits. TDM also induced atrophy of the thymus and spleen due to apoptosis. By contrast, sulfolipid (2,3,6,6'-tetraacyl trehalose 2'-sulfate) induced neither toxicity, nor granuloma formation, nor atrophy of the thymus and spleen. In rabbits the histopathological changes were more dramatic than in mice. The rabbit model may. be more sensitive and may provide more information on the beneficial or pathological effects of TDM.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available