Journal
PATHOLOGY INTERNATIONAL
Volume 50, Issue 6, Pages 480-485Publisher
BLACKWELL SCIENCE ASIA
DOI: 10.1046/j.1440-1827.2000.01069.x
Keywords
isoproterenol; myocardial injury; S100A4; S100A11
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S-100 proteins (S100) are characterized by calcium-binding ability with two structural EF hands. Several S100 are expressed in cardiomyocytes and thought to play a crucial role in calcium signaling. To examine whether the expression of S100 is a response to detectable myocardial damage or regeneration, we investigated, immunohistochemically, the expression of S100A4 and S100A11 in the isoproterenol (ISP)-treated rat heart. Definite expression of S100A4 and S100A11 was demonstrated in normal cardiomyocytes, and their staining patterns were enhanced in the ISP-treated rat heart, suggesting the possible involvement of S1-A4 and S100A11 in ISP-induced myocardial damage.
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