Journal
THERAPEUTIC DRUG MONITORING
Volume 22, Issue 3, Pages 354-365Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00007691-200006000-00019
Keywords
population pharmacokinetic modeling; pharmacodynamic modeling; parametric methods; nonparametric methods
Funding
- NCRR NIH HHS [RR11526, RR 01629] Funding Source: Medline
- NLM NIH HHS [LM 05401] Funding Source: Medline
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As clinicians acquire experience with the clinical and pharmacokinetic behavior of a drug, it is usually optimal to record this experience in the form of a population pharmacokinetic model, and then to relate the behavior of the model to the clinical effects of the drug or to a linked pharmacodynamic model. The role of population modeling is thus to describe and record clinical experience with the behavior of a drug in a certain group or population of patients or subjects.
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